Catalog No.: PC-20786Not For Human Use, Lab Use Only.
RG108 (N-Phthalyl-L-tryptophan) is small molecule that effectively blocks DNA methyltransferases (DNMT) in vitro (IC50=115 nM) and does not cause covalent enzyme trapping in human cell lines.
RG108 (N-Phthalyl-L-tryptophan) is small molecule that effectively blocks DNA methyltransferases (DNMT) in vitro (IC50=115 nM) and does not cause covalent enzyme trapping in human cell lines.
RG108 efficiently blocks DNA methylation, both in a cell-free in vitro system and in human cancer cell lines.
RG108 caused demethylation and reactivation of tumor suppressor genes, but it did not affect the methylation of centromeric satellite sequences. and dihydroartemisinin treatment synergize to trigger ferroptosis in cancer cells
Physicochemical Properties
M.Wt
334.33
Formula
C19H14N2O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-Phthalyl-L-tryptophan
References
1. Bodo Brueckner, et al. Cancer Res. 2005 Jul 15;65(14):6305-11.
