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Chemical Structure : RG108
CAS No.: 48208-26-0
Catalog No.: PC-20786Not For Human Use, Lab Use Only.
RG108 (N-Phthalyl-L-tryptophan) is small molecule that effectively blocks DNA methyltransferases (DNMT) in vitro (IC50=115 nM) and does not cause covalent enzyme trapping in human cell lines.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $298 | In stock | |
| 250 mg | Get quote |
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RG108 (N-Phthalyl-L-tryptophan) is small molecule that effectively blocks DNA methyltransferases (DNMT) in vitro (IC50=115 nM) and does not cause covalent enzyme trapping in human cell lines.
RG108 efficiently blocks DNA methylation, both in a cell-free in vitro system and in human cancer cell lines.
RG108 caused demethylation and reactivation of tumor suppressor genes, but it did not affect the methylation of centromeric satellite sequences. and dihydroartemisinin treatment synergize to trigger ferroptosis in cancer cells
| M.Wt | 334.33 | |
| Formula | C19H14N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-Phthalyl-L-tryptophan |
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1. Bodo Brueckner, et al. Cancer Res. 2005 Jul 15;65(14):6305-11.
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