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Chemical Structure : RGB-286199
Catalog No.: PC-21090Not For Human Use, Lab Use Only.
RGB-286199 (GPC-286199) is a potent broad spectrum CDKs (cyclin dependent kinases) inhibitor with IC50 of 5-100 nM against CDKs 1-6, shows antiproliferative activity in vitro and in vivo.
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RGB-286199 (GPC-286199) is a potent broad spectrum CDKs (cyclin dependent kinases) inhibitor with IC50 of 5-100 nM against CDKs 1-6, shows antiproliferative activity in vitro and in vivo.
RGB-286199 (50 nM) causes loss of phosphorylation of Rb protein, accompanied by loss of cyclin A protein, in the human colon carcinoma cell line HCT-116 treated in vitro.
RGB-286199 has significant antitumor efficacy in vivo against several human xenograft models at tolerated doses.
| M.Wt | 573.65 | |
| Formula | C30H35N7O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shaoshan Wang, et al. Cancer Res (2005) 65 (9_Supplement): 1048.
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