Catalog No.: PC-21090Not For Human Use, Lab Use Only.
RGB-286199 (GPC-286199) is a potent broad spectrum CDKs (cyclin dependent kinases) inhibitor with IC50 of 5-100 nM against CDKs 1-6, shows antiproliferative activity in vitro and in vivo.
RGB-286199 (GPC-286199) is a potent broad spectrum CDKs (cyclin dependent kinases) inhibitor with IC50 of 5-100 nM against CDKs 1-6, shows antiproliferative activity in vitro and in vivo.
RGB-286199 (50 nM) causes loss of phosphorylation of Rb protein, accompanied by loss of cyclin A protein, in the human colon carcinoma cell line HCT-116 treated in vitro.
RGB-286199 has significant antitumor efficacy in vivo against several human xenograft models at tolerated doses.
