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RGH-122

Chemical Structure : RGH-122

CAS No.: 2355304-05-9

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RGH-122 (RGH122)

Catalog No.: PC-21614Not For Human Use, Lab Use Only.

RGH-122 is a potent, selective, and orally bioavailable V1a receptor antagonist with Ki/IC50 of 0.3/0.9 nM (hV1a) respectively, >100-fold selectiive over V2 receptor.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

RGH-122 is a potent, selective, and orally bioavailable V1a receptor antagonist with Ki/IC50 of 0.3/0.9 nM (hV1a) respectively, >100-fold selectiive over V2 receptor.
RGH-122 shows over 6000-fold and over 10 000-fold selectivity over V1b receptors and hERG channels.
RGH-122 (0.5, 1.5, and 5 mg/kg, oral) restored social recognition memory deficit induced by prenatal valproate exposure in male rats after an 8 day treatment regimen.

Physicochemical Properties

M.Wt 452.94
Formula C24H25ClN4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8'-Chloro-1'-[trans-4-(pyridin-2-yloxy)cyclohexyl]-4'H,6'H-spiro[1,3-dioxolane-2,5'-[1,2,4]triazolo[4,3-a][1]benzazepine]

References

1. Ferenc Baska, et al. J Med Chem. 2024 Jan 2. doi: 10.1021/acs.jmedchem.3c01868.

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