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Chemical Structure : RIST4721
Catalog No.: PC-49866Not For Human Use, Lab Use Only.
RIST 4721 (Vimnerixin, AZD 4721) is a potent, specific and orally active antagonist of CXCR2, potently inhibits neutrophil chemotaxis with IC50 of 17 nM.
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RIST 4721 (Vimnerixin, AZD 4721) is a potent, specific and orally active antagonist of CXCR2, potently inhibits neutrophil chemotaxis with IC50 of 17 nM.
RIST 4721 (10 nM and 100 nM) potently inhibits keratinocyte chemokine (KC) mediated chemotaxis in a dose-dependent manner.
RIST4721 (1 μM) completely abrogates any additional chemotaxis stimulated with KC, indicating the complete inhibition of CXCR2 activities.
RIST4721 does not change FBS-mediated responses, indicating chemotaxis inhibition is CXCR2-specific.
RIST4721 does not alter the proliferation rates of mitotically active neutrophil progenitors.
RIST4721-treated neutrophils exhibits robust phagocytosis and reactive oxygen species production, confirming drug specificity to chemotaxis inhibition.
| M.Wt | 472.55 | |
| Formula | C19H25FN4O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Szymczak K, et al. Biomedicines. 2023 Feb 7;11(2):479.
2. Bissonnette R, et al. Dermatol Ther (Heidelb). 2021 Dec;11(6):2179-2193.
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