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Chemical Structure : RJW100
Catalog No.: PC-38407Not For Human Use, Lab Use Only.
RJW100 (RJW 100) is a phospholipid mimetic as liver receptor homolog-1 (LRH-1, NR5A2) agonist with pEC50 of 6.6 and 7.5 for (LRH-1) and steroidogenic factor-1 (SF-1, NR5A1), respectively.
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RJW100 (RJW 100) is a phospholipid mimetic as liver receptor homolog-1 (LRH-1, NR5A2) agonist with pEC50 of 6.6 and 7.5 for (LRH-1) and steroidogenic factor-1 (SF-1, NR5A1), respectively.
RJW100 interacts with the targeted residues in crystal structures and improve binding affinity, LRH-1 transcriptional activity, and conformational changes at a key allosteric site.
RJW100 markedly improves colonic histopathology and disease-related weight loss in a murine T cell transfer model of colitis.
| M.Wt | 386.57 | |
| Formula | C28H34O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Suzanne G Mays, et al. Cell Chem Biol. 2022 Mar 15;S2451-9456(22)00089-7.
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