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RJW100

Chemical Structure : RJW100

CAS No.: 1276664-20-0

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RJW100 (RJW 100)

Catalog No.: PC-38407Not For Human Use, Lab Use Only.

RJW100 (RJW 100) is a phospholipid mimetic as liver receptor homolog-1 (LRH-1, NR5A2) agonist with pEC50 of 6.6 and 7.5 for (LRH-1) and steroidogenic factor-1 (SF-1, NR5A1), respectively.

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    Biological Activity

    RJW100 (RJW 100) is a phospholipid mimetic as liver receptor homolog-1 (LRH-1, NR5A2) agonist with pEC50 of 6.6 and 7.5 for (LRH-1) and steroidogenic factor-1 (SF-1, NR5A1), respectively.
    RJW100 interacts with the targeted residues in crystal structures and improve binding affinity, LRH-1 transcriptional activity, and conformational changes at a key allosteric site.
    RJW100 markedly improves colonic histopathology and disease-related weight loss in a murine T cell transfer model of colitis.

    Physicochemical Properties

    M.Wt 386.57
    Formula C28H34O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1R,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylvinyl)-1,2,3,3a,6,6a-hexahydropentalen-1-ol

    References

    1. Suzanne G Mays, et al. Cell Chem Biol. 2022 Mar 15;S2451-9456(22)00089-7.

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