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RK-0404678

Chemical Structure : RK-0404678

CAS No.: 82531-06-4

RK-0404678 (RK0404678)

Catalog No.: PC-47063Not For Human Use, Lab Use Only.

RK-0404678 is a potent, small molecule inhibitor of DENV type 2 (DENV2) RdRp activities, exhibits in cellulo antiviral EC50 of 6.0 uM for DENV2.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

RK-0404678 is a potent, small molecule inhibitor of DENV type 2 (DENV2) RdRp activities, exhibits in cellulo antiviral EC50 of 6.0 uM for DENV2.
RK-0404678 inhibited the RdRp activities with IC50 values of 46.2-445 μM for the NS5 proteins from DENV1-4, and exhibited antiviral activities with EC50 values of 6.0-31.9 μM for the DENV1-4 infections.
RK-0404678 possesses a high genetic barrier to the emergence of resistant viruses.

Physicochemical Properties

M.Wt 210.203
Formula C9H6O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-oxobenzo[d][1,3]oxathiol-5-yl acetate

References

1. Hideaki Shimizu, et al. PLoS Negl Trop Dis. 2019 Nov 18;13(11):e0007894.

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