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Chemical Structure : RK-0404678
Catalog No.: PC-47063Not For Human Use, Lab Use Only.
RK-0404678 is a potent, small molecule inhibitor of DENV type 2 (DENV2) RdRp activities, exhibits in cellulo antiviral EC50 of 6.0 uM for DENV2.
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RK-0404678 is a potent, small molecule inhibitor of DENV type 2 (DENV2) RdRp activities, exhibits in cellulo antiviral EC50 of 6.0 uM for DENV2.
RK-0404678 inhibited the RdRp activities with IC50 values of 46.2-445 μM for the NS5 proteins from DENV1-4, and exhibited antiviral activities with EC50 values of 6.0-31.9 μM for the DENV1-4 infections.
RK-0404678 possesses a high genetic barrier to the emergence of resistant viruses.
| M.Wt | 210.203 | |
| Formula | C9H6O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hideaki Shimizu, et al. PLoS Negl Trop Dis. 2019 Nov 18;13(11):e0007894.
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