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RK-0404678

Chemical Structure : RK-0404678

CAS No.: 82531-06-4

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RK-0404678 (RK0404678)

Catalog No.: PC-47063Not For Human Use, Lab Use Only.

RK-0404678 is a potent, small molecule inhibitor of DENV type 2 (DENV2) RdRp activities, exhibits in cellulo antiviral EC50 of 6.0 uM for DENV2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    RK-0404678 is a potent, small molecule inhibitor of DENV type 2 (DENV2) RdRp activities, exhibits in cellulo antiviral EC50 of 6.0 uM for DENV2.
    RK-0404678 inhibited the RdRp activities with IC50 values of 46.2-445 μM for the NS5 proteins from DENV1-4, and exhibited antiviral activities with EC50 values of 6.0-31.9 μM for the DENV1-4 infections.
    RK-0404678 possesses a high genetic barrier to the emergence of resistant viruses.

    Physicochemical Properties

    M.Wt 210.203
    Formula C9H6O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-oxobenzo[d][1,3]oxathiol-5-yl acetate

    References

    1. Hideaki Shimizu, et al. PLoS Negl Trop Dis. 2019 Nov 18;13(11):e0007894.

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