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RN-1 dihydrochloride

Chemical Structure : RN-1 dihydrochloride

CAS No.: 1781835-13-9

RN-1 dihydrochloride (LSD1 Inhibitor IV)

Catalog No.: PC-61643Not For Human Use, Lab Use Only.

RN-1 dihydrochloride is a potent, irreversible, brain-penetrant inhibitor of LSD1 with IC50 of 70 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RN-1 dihydrochloride is a potent, irreversible, brain-penetrant inhibitor of LSD1 with IC50 of 70 nM.
RN-1 dihydrochloride shows much less effectivity against MAO-A and MAO-B (IC50=0.51 and 2.8 uM, respectively).
RN-1 dihydrochloride abolishes long-term memory formation without affecting short-term memory in a mouse model.
RN-1 dihydrochloride also induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice.

Physicochemical Properties

M.Wt 452.42
Formula C23H29N3O2.2HCl
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(4-methyl-1-piperazinyl)-2-[[(1R*,2S*)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanone dihydrochloride

References

1. Neelamegam R, et al. ACS Chem Neurosci. 2012 Feb 15;3(2):120-128.

2. Cui S, et al. Blood. 2015 Jul 16;126(3):386-96.

3. Rivers A, et al. Haematologica. 2016 Jun;101(6):688-97.

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