RN-9893 | TRPV4 inhibitor | Probechem Biochemicals

Chemical Structure : RN-9893

CAS No.: 1803003-68-0

RN-9893 (RN9893;RN 9893)

Catalog No.: PC-70039Not For Human Use, Lab Use Only.

RN-9893 (RN9893) is a potent, selective orally-bioavailable TRPV4 antagonist with IC50 of 320, 420 and 660 nM for mouse, human and rat TRPV4 channels, respectively.

Packing	Price	Stock
5 mg	$118	In stock
10 mg	$178	In stock
25 mg	$278	In stock
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Biological Activity

RN-9893 (RN9893) is a potent, selective orally-bioavailable TRPV4 antagonist with IC50 of 320, 420 and 660 nM for mouse, human and rat TRPV4 channels, respectively.
RN-9893 shows >15-fold selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8, and a panel of 54 other common biological targets.

Physicochemical Properties

M.Wt	500.493
Formula	C21H23F3N4O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((4-isopropylpiperazin-1-yl)sulfonyl)phenyl)-2-nitro-4-(trifluoromethyl)benzamide

References

1. Wei ZL, et al. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4011-5.

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RN-9893 (RN9893;RN 9893)

Biological Activity

Physicochemical Properties

References

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