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RO 2443

Chemical Structure : RO 2443

CAS No.: 1416663-79-0

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RO 2443 (RO2443)

Catalog No.: PC-62020Not For Human Use, Lab Use Only.

RO 2443 is a potent, dual MDM2/MDMX antagonist that inhibits both MDM2 (IC50=33 nM) and MDMX (IC50=41 nM) binding to p53, but poor water solubility does not allow for a meaningful assessment of its cellular activity..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    RO 2443 is a potent, dual MDM2/MDMX antagonist that inhibits both MDM2 (IC50=33 nM) and MDMX (IC50=41 nM) binding to p53, but poor water solubility does not allow for a meaningful assessment of its cellular activity.

    Physicochemical Properties

    M.Wt 401.798
    Formula C20H14ClF2N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2,4-Imidazolidinedione, 5-[(6-chloro-7-methyl-1H-indol-3-yl)methylene]-3-[(3,4-difluorophenyl)methyl]-

    References

    1. Graves B, et al. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11788-93.

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