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RO 5073012

Chemical Structure : RO 5073012

CAS No.: 1020814-70-3

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RO 5073012 (RO5073012, RO-5073012)

Catalog No.: PC-61076Not For Human Use, Lab Use Only.

RO 5073012 is a potent, selective, orally active TAAR1 partial agonist with Ki of 6 nM, EC50 of 23 nM (hTAAR1), 140-fold selectivity over β2 adrenergic receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    RO 5073012 is a potent, selective, orally active TAAR1 partial agonist with Ki of 6 nM, EC50 of 23 nM (hTAAR1), 140-fold selectivity over β2 adrenergic receptors.
    RO 5073012 restores the psychostimulant effects of amphetamine on locomotion in Taar1 transgenic mice.
    RO 5073012 exhibits good pharmacokinetic profile after oral administration in rodents and is active in a CNS behavioural models.

    Physicochemical Properties

    M.Wt 249.742
    Formula C13H16ClN3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((1H-imidazol-4-yl)methyl)-4-chloro-N-isopropylaniline

    References

    1. Galley G, et al. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5244-8.

    2. Revel FG, et al. Neuropsychopharmacology. 2012 Nov;37(12):2580-92.

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