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RO5263397

Chemical Structure : RO5263397

CAS No.: 1357266-05-7

RO5263397 (RO 5263397, RO-5263397)

Catalog No.: PC-61072Not For Human Use, Lab Use Only.

RO 5263397 is a highly potent, selective and orally bioavailable trace amine-associated receptor 1 (TAAR1) partial agonist with EC50 of 17 nM, >1,000-fold selectivity over human adrenergic α2A receptor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RO 5263397 is a highly potent, selective and orally bioavailable trace amine-associated receptor 1 (TAAR1) partial agonist with EC50 of 17 nM, >1,000-fold selectivity over human adrenergic α2A receptor.
RO 5263397 shows EC50 of 35 nM for rat TRRA1.
RO 5263397 blocks psychostimulant-induced hyperactivity and produces a brain activation pattern reminiscent of the antipsychotic drug olanzapine in vivo, does not induce catalepsy or weight gain, promotes vigilance in rats and shows pro-cognitive and antidepressant-like properties in rodent and primate models.

Physicochemical Properties

M.Wt 194.209
Formula C10H11FN2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-4-(3-fluoro-2-methylphenyl)-4,5-dihydrooxazol-2-amine

References

1. Revel FG, et al. Mol Psychiatry. 2013 May;18(5):543-56.

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