RORγt-IN-9a | RORγt inhibitor | Probechem Biochemicals

Chemical Structure : RORγt-IN-9a

RORγt-IN-9a (RORγt inhibitor 9a)

Catalog No.: PC-60488Not For Human Use, Lab Use Only.

RORγt-IN-9a is a potent, selective, CNS penetrant, orally bioavailable RORγt inhibitor with pIC50 of 8.3 in FRET assays.

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Biological Activity

RORγt-IN-9a is a potent, selective, CNS penetrant, orally bioavailable RORγt inhibitor with pIC50 of 8.3 in FRET assays.
RORγt-IN-9a has TH17 pEC50 of 7.3, demonstrates excellent in vivo efficacy in EAE mice.

Physicochemical Properties

M.Wt	518.328
Formula	C22H16Cl2F3NO4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2,6-dichloro-2'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)-2-(4-(methylsulfonyl)phenyl)acetamide

References

1. Wang Y, et al. ACS Med Chem Lett. 2015 May 26;6(7):787-92.

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RORγt-IN-9a (RORγt inhibitor 9a)

Biological Activity

Physicochemical Properties

References

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