RORγt inverse agonist 32

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Chemical Structure : RORγt inverse agonist 32

Catalog No.: PC-35570Not For Human Use, Lab Use Only.

RORγt inverse agonist 32 is a potent, orally bioavailable inverse agonist of RORγt with IC50 of 9 nM in SPA binding assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RORγt inverse agonist 32 is a potent, orally bioavailable inverse agonist of RORγt with IC50 of 9 nM in SPA binding assays.
RORγt inverse agonist 32 inhibits IL-17 production from human primary TH17 cells with IC50 of 57 n.
RORγt inverse agonist 32 also exhibits favorable PK in rodents.

Physicochemical Properties

M.Wt	515.574
Formula	C24H22FN3O5S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Acetamido-N-[4-(5-cyano-3-fluoro-2-methoxy-phenyl)-2-thienyl]-2-(4-ethylsulfonylphenyl)acetamide

References

1. Narjes F, et al. J Med Chem. 2018 Aug 10. doi: 10.1021/acs.jmedchem.8b00783.

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