RORγ inhibitor Cpd 21

Chemical Structure : RORγ inhibitor Cpd 21

Catalog No.: PC-26232Not For Human Use, Lab Use Only.

RORγ inhibitor Cpd 21 is potent, selective RORγ inhibitor with EC50 of 84 nM (hRORγ).

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Biological Activity

RORγ inhibitor Cpd 21 is potent, selective RORγ inhibitor with EC50 of 84 nM (hRORγ).
Cpd 21 showed no significant antagonist activity against hRORα, hRORβ, mLXRα, hRXRα, or hPPARδ, nor notable agonist activity against hPPARγ (EC50 > 0.512 μM for all targets).
Cpd 21 inhibited IL-17 production induced by anti-CD3/anti-CD28 antibody stimulation in human PBMCs with an IC50 value of 1.0 uM.

Physicochemical Properties

M.Wt	350.89
Formula	C19H27ClN2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(tert-butyl)-4-(3-chloro-4-(neopentyloxy)phenyl)-3,4-dihydropyrimidin-2(1H)-one

References

1. Taku Ikenogami, et al. Bioorg Med Chem Lett. 2026 Mar:132:130494.

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