Chemical Structure : RPT193
CAS No.:
2366152-15-8
RPT193
(Zelnecirnon, RPT-193)
Catalog No.: PC-49464Not For Human Use, Lab Use Only.
RPT193 (RPT-193) is a highly potent, selective and orally active CCR4 antagonist, inhibits CCL22- induces human Th2 chemotaxis with IC50 of 370 nM.
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Purity & Documentation Purity:
>98% (HPLC)
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Biological Activity
RPT193 (Zelnecirnon, RPT-193) is a highly potent, selective and orally active CCR4 antagonist, inhibits CCL22- induces human Th2 chemotaxis with IC50 of 370 nM.
RPT193 (Zelnecirnon) shows greater potency against Th2 chemotaxis than previous CCR4 antagonists (AZD-2098, GSK2239633).
RPT193 (Zelnecirnon) (100 mg/kg, oral) reduces skin inflammation in an acute OVA-induced atopic dermatitis model, significantly reduces Th2 cell migration into inflamed skin.
Physicochemical Properties
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M.Wt
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566.95
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Formula
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C27H34Cl3N5O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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trans-3-[(3R)-3-[1-[5-Chloro-4-[[(1R)-1-(2,4-dichlorophenyl)ethyl]amino]-6-methyl-2-pyrimidinyl]-3-azetidinyl]-1-piperidinyl]-1-methylcyclobutanecarboxylic acid
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References
1. Robert Bissonnette, et al. Allergy. 2024 Apr;79(4):924-936.
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