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Chemical Structure : RPT193
CAS No.: 2366152-15-8
Catalog No.: PC-49464Not For Human Use, Lab Use Only.
RPT193 (RPT-193) is a highly potent, selective and orally active CCR4 antagonist, inhibits CCL22- induces human Th2 chemotaxis with IC50 of 370 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $498 | In stock | |
| 10 mg | $758 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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RPT193 (Zelnecirnon, RPT-193) is a highly potent, selective and orally active CCR4 antagonist, inhibits CCL22- induces human Th2 chemotaxis with IC50 of 370 nM.
RPT193 (Zelnecirnon) shows greater potency against Th2 chemotaxis than previous CCR4 antagonists (AZD-2098, GSK2239633).
RPT193 (Zelnecirnon) (100 mg/kg, oral) reduces skin inflammation in an acute OVA-induced atopic dermatitis model, significantly reduces Th2 cell migration into inflamed skin.
| M.Wt | 566.95 | |
| Formula | C27H34Cl3N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
trans-3-[(3R)-3-[1-[5-Chloro-4-[[(1R)-1-(2,4-dichlorophenyl)ethyl]amino]-6-methyl-2-pyrimidinyl]-3-azetidinyl]-1-piperidinyl]-1-methylcyclobutanecarboxylic acid |
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