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RR6

Chemical Structure : RR6

CAS No.: 1351758-37-6

RR6 (Vanin inhibitor RR6)

Catalog No.: PC-45557Not For Human Use, Lab Use Only.

RR6 is a selective, reversible, and competitive Vanin inhibitor with IC50 of 0.54 uM for hVVN1 pantetheinase.

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Biological Activity

RR6 is a selective, reversible, and competitive Vanin inhibitor with IC50 of 0.54 uM for hVVN1 pantetheinase.
RR6 completely inhibits plasma vanin activity and caused alterations of plasma lipid concentrations in rats.
RR6 inhibits PDGF-induced SMC proliferation and protects SMCs from TNF-α-induced apoptosis in vitro, attenuates transplant vasculopathy in rat aortic allografts; orally bioactive.

Physicochemical Properties

M.Wt 293.3581
Formula C16H23NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Butanamide, 2-hydroxy-3-(hydroxymethyl)-3-methyl-N-(3-oxo-4-phenylbutyl)-, (2R)-

References

1. Jansen PA, et al. ACS Chem Biol. 2013 Mar 15;8(3):530-4.

2. van Diepen JA, et al. Sci Rep. 2016 Mar 2;6:21906.

3. Wedel J, et al. Transplantation. 2016 Aug;100(8):1656-66.

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