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RTC-30

Chemical Structure : RTC-30

CAS No.: 1423077-95-5

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RTC-30 (RTC30)

Catalog No.: PC-62748Not For Human Use, Lab Use Only.

RTC-30 is an orally active, dual pathway inhibitor of PI3K-AKT and RAS-ERK signaling via putative activation of the tumor suppressor PP2A, exhibits GI50 of 15 uM against H1650 lung adenocarcinoma cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    RTC-30 is an orally active, dual pathway inhibitor of PI3K-AKT and RAS-ERK signaling via putative activation of the tumor suppressor PP2A, exhibits GI50 of 15 uM against H1650 lung adenocarcinoma cells.
    RTC-30 significantly decrease tumor growth in H1650 xenograft in mice.

    Physicochemical Properties

    M.Wt 492.513
    Formula C24H23F3N2O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-N-(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-2-hydroxypropyl)-4-(trifluoromethoxy)benzenesulfonamide

    References

    1. Kastrinsky DB, et al. Bioorg Med Chem. 2015 Oct 1;23(19):6528-34.

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