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RTC-5

Chemical Structure : RTC-5

CAS No.: 1423077-49-9

RTC-5 (PP2A activator RTC-5, TRC-382, TRC382)

Catalog No.: PC-62747Not For Human Use, Lab Use Only.

RTC-5 is a dual pathway inhibitor of PI3K-AKT and RAS-ERK signaling via putative activation of the tumor suppressor PP2A, exhibits GI50 of 12.6 uM against H1650 lung adenocarcinoma cells.

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Biological Activity

RTC-5 (PP2A activator RTC-5, TRC-382) is a dual pathway inhibitor of PI3K-AKT and RAS-ERK signaling via putative activation of the tumor suppressor PP2A, exhibits GI50 of 12.6 uM against H1650 lung adenocarcinoma cells.
RTC-5 (PP2A activator RTC-5, TRC-382) significantly decreases tumor growth in H1650 xenograft in mice.

Physicochemical Properties

M.Wt 510.956
Formula C24H22ClF3N2O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl)-4-(trifluoromethoxy)benzenesulfonamide

References

1. Kastrinsky DB, et al. Bioorg Med Chem. 2015 Oct 1;23(19):6528-34.

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