RTI-118 | NPSR antagonist | Probechem Biochemicals

Chemical Structure : RTI-118

RTI-118 (RTI 118)

Catalog No.: PC-21472Not For Human Use, Lab Use Only.

RTI-118 is a potent, selective neuropeptide S receptor (NPSR, GPR154) antagonist.

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Biological Activity

RTI-118 is a potent, selective neuropeptide S receptor (NPSR, GPR154) antagonist.
RTI-118 (5–30 mg/kg i.p.) produced a dose-dependent and nearly complete elimination of cocaine self-administration, and was more potent and efficacious to reduce cocaine self-administration than food-maintained responding.
RTI-118 (1–20 mg/kg i.p.) also blocked cocaine, cue-, and stress-induced reinstatement of extinguished cocaine self-administration.

Physicochemical Properties

M.Wt	448.57
Formula	C26H32N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-oxo-1,1-diphenyl-N-(2-(piperidin-1-yl)ethyl)tetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxamide

References

1. Zhang Y, et al. Bioorg Med Chem Lett. 2008;18:4064–4067.

2. Julie S Bonano, et al. Eur J Pharmacol. 2014 Nov 15:743:98-105.

3. Christopher D Schmoutz, et al. Pharmacol Biochem Behav. 2012 Dec;103(2):332-7.

RTI-118 (RTI 118)

Biological Activity

Physicochemical Properties

References

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