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Chemical Structure : RTICBM-189
CAS No.: 551909-15-0
Catalog No.: PC-72730Not For Human Use, Lab Use Only.
RTICBM-189 is a potent, selective, brain-penetrant CB1 negative allosteric modulator (NAM) with pIC50 of 7.54 in Ca2+ assay, 5.29 in GTPγS assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 100 mg | $658 | In stock | |
| 1 g | Get quote |
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RTICBM-189 is a potent, selective, brain-penetrant CB1 negative allosteric modulator (NAM) with pIC50 of 7.54 in Ca2+ assay, 5.29 in GTPγS assay.
RTICBM-189 shows no activity at >50 protein targets and excellent brain permeation but relatively low metabolic stability in rat liver microsomes.
RTICBM-189 (10 mg/kg, i.p.) significantly and selectively attenuated the reinstatement of the cocaine-seeking behavior in rats without affecting locomotion.
| M.Wt | 309.19 | |
| Formula | C15H14Cl2N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-(3-chlorophenethyl)-3-(4-chlorophenyl)urea |
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1. Nguyen T, et al. J Med Chem. 2022 Jan 13;65(1):257-270.
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