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RTICBM-74

Chemical Structure : RTICBM-74

CAS No.: 2130881-32-0

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RTICBM-74 (RTICBM74)

Catalog No.: PC-72728Not For Human Use, Lab Use Only.

RTICBM-74 is a potent, selective, brain-penetrant CB1 negative allosteric modulator (NAM) with IC50 of 23 nM in Ca2+ assays.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

RTICBM-74 is a potent, selective, brain-penetrant CB1 negative allosteric modulator (NAM) with IC50 of 23 nM in Ca2+ assays.
RTICBM-74 displays excellent half-life and low clearance against rat liver microsomes and hepatocytes, and excellent brain penetrance in rats.
RTICBM-74 specifically reduces alcohol intake across a range of doses in male or female Wistar or Long-Evans rats, reduces alcohol intake and does not affect locomotion or sucrose self-administration.

Physicochemical Properties

M.Wt 340.782
Formula C19H14ClFN2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(4-Chlorophenyl)-3-(4'-fluoro-[1,1'-biphenyl]-4-yl)urea

References

1. Nguyen T, et al. J Med Chem. 2017 Sep 14;60(17):7410-7424.

2. Lovelock DF, et al. J Pharmacol Exp Ther. 2022 Mar;380(3):153-161.

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