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RU-SKI 43 hydrochloride

Chemical Structure : RU-SKI 43 hydrochloride

CAS No.:

RU-SKI 43 hydrochloride (RU-SKI43 hydrochloride)

Catalog No.: PC-45464Not For Human Use, Lab Use Only.

A small molecule inhibitor of Hhat (Hedgehog acyltransferase) with IC50 of 0.85 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A small molecule inhibitor of Hhat (Hedgehog acyltransferase) with IC50 of 0.85 uM; specific to Shh palmitoylation and no effect for palmitoylation of H-Ras, Fyn and myristoylation of c-Src; reduces pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling, inhibits two key proliferative pathways regulated by Akt and mTOR.

Physicochemical Properties

M.Wt 423.0117
Formula C22H31ClN2O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 51 mg/mL

Chemical Name/SMILES

Ethanone, 1-[6,7-dihydro-4-[(3-methylphenoxy)methyl]thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-, hydrochloride

References

1. Petrova E, et al. Nat Chem Biol. 2013 Apr;9(4):247-9.

2. Petrova E, et al. Oncogene. 2015 Jan 8;34(2):263-8.

3. Matevossian A, et al. Mol Cancer. 2015 Apr 1;14:72.

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