RU.521 (RU521, RU-320521) | cGAS inhibitor

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Chemical Structure : RU.521

CAS No.: 2262452-06-0

RU.521 (RU521, RU-320521 )

Catalog No.: PC-60018Not For Human Use, Lab Use Only.

RU.521 (RU521, RU-320521) is a potent, selective cyclic GMP-AMP synthase (cGAS) inhibitor with Kd of 36.2 nM.

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5 mg	$98	In stock
10 mg	$158	In stock
25 mg	$278	In stock
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Biological Activity

RU.521 (RU521, RU-320521) is a potent, selective cyclic GMP-AMP synthase (cGAS) inhibitor with Kd of 36.2 nM.
RU.521 inhibits cGAS-mediated interferon upregulation in cellular assays, with no effect on inflammatory pathways independent of cGAS.
RU.521 suppresses the chronically elevated levels of type I interferon in primary macrophages from mice model of AGS (Aicardi-Goutières syndrome).

Physicochemical Properties

M.Wt	415.23
Formula	C19H12Cl2N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[1-(6,7-dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-pyrazol-4-yl]-3H-isobenzofuran-1-one

References

1. Vincent J, et al. Nat Commun. 2017 Sep 29;8(1):750.

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RU.521 (RU521, RU-320521 )

Biological Activity

Physicochemical Properties

References

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