Chemical Structure : RU.521
CAS No.: 2262452-06-0
Catalog No.: PC-60018Not For Human Use, Lab Use Only.
RU.521 (RU521, RU-320521) is a potent, selective cyclic GMP-AMP synthase (cGAS) inhibitor with Kd of 36.2 nM.
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RU.521 (RU521, RU-320521) is a potent, selective cyclic GMP-AMP synthase (cGAS) inhibitor with Kd of 36.2 nM.
RU.521 inhibits cGAS-mediated interferon upregulation in cellular assays, with no effect on inflammatory pathways independent of cGAS.
RU.521 suppresses the chronically elevated levels of type I interferon in primary macrophages from mice model of AGS (Aicardi-Goutières syndrome).
M.Wt | 415.23 | |
Formula | C19H12Cl2N4O3 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
3-[1-(6,7-dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-pyrazol-4-yl]-3H-isobenzofuran-1-one |
1. Vincent J, et al. Nat Commun. 2017 Sep 29;8(1):750.
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