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RUSKI-201

Chemical Structure : RUSKI-201

CAS No.: 1458031-48-5

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RUSKI-201 (RUSKI 201, RUSKI201)

Catalog No.: PC-70165Not For Human Use, Lab Use Only.

RUSKI-201 is a potent, selective and cell active Hedgehog acyltransferase (Hhat) inhibitor with IC50 of 0.87 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    RUSKI-201 is a potent, selective and cell active Hedgehog acyltransferase (Hhat) inhibitor with IC50 of 0.87 uM.
    RUSKI-201 blocks Hh signaling in H520, Panc-1, and MCF-7 coculture with Shh-Light2 cells (IC50=4.8 uM, 7.8 uM, and 8.5 uM, respectively).
    RUSKI-201 selectively inhibits Hh palmitoylation over a panel of >100 palmitoylated substrates in cells.

    Physicochemical Properties

    M.Wt 357.516
    Formula C20H27N3OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-[6,7-Dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]ethanone

    References

    1. Rodgers UR, et al. ACS Chem Biol. 2016 Dec 16;11(12):3256-3262.

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