Chemical Structure : RX-207
CAS No.:
918328-92-4
RX-207
(RX207)
Catalog No.: PC-20580Not For Human Use, Lab Use Only.
RX-207 (RX207) is a small molecule inhibitor of protein binding to glycosaminoglycans (SMIGs), inhibits protein binding to glycosaminoglycans (GAGs), inhibits inflammatory neutrophil adhesion and activity in vitro and in vivo.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RX-207 (RX207) is a small molecule inhibitor of protein binding to glycosaminoglycans (SMIGs), inhibits protein binding to glycosaminoglycans (GAGs), inhibits inflammatory neutrophil adhesion and activity in vitro and in vivo.
RX-207 (50 mg/kg) inhibited neutrophil migration into the peritoneal cavity by 37% in a mouse model of thioglycollate-induced peritonitis.
Intramuscular (i.m.) injection of RX-207 (1 mg/kg, 0.1 mL) inhibited carrageenan-induced paw edema in mice (32%).
RX-207 (30 uM) inhibited binding of the pro-inflammatory chemokine, MCP-3, to heparin, a highly sulfated form of the cell surface GAG, heparan sulfate.
RX-207 (30 μM) inhibited binding of the pro-inflammatory chemokine, IP-10, to the extracellular matrix GAG, chondroitin sulfate.
Physicochemical Properties
|
M.Wt
|
382.51
|
|
Formula
|
C22H30N4O2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
O=C(C1=CC(N=C2N3CCCCC2)=C(C=C1)C3=O)NC4CCN(C(C)C)CC4
|
References
1. Stefan Juhas, et al. Inflammation. 2018 Feb;41(1):307-314.
Contact Us
sales@probechem.com
