Chemical Structure : RX-207
CAS No.:
918328-92-4
RX-207
(RX207)
Catalog No.: PC-20580Not For Human Use, Lab Use Only.
RX-207 (RX207) is a small molecule inhibitor of protein binding to glycosaminoglycans (SMIGs), inhibits protein binding to glycosaminoglycans (GAGs), inhibits inflammatory neutrophil adhesion and activity in vitro and in vivo.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RX-207 (RX207) is a small molecule inhibitor of protein binding to glycosaminoglycans (SMIGs), inhibits protein binding to glycosaminoglycans (GAGs), inhibits inflammatory neutrophil adhesion and activity in vitro and in vivo.
RX-207 (50 mg/kg) inhibited neutrophil migration into the peritoneal cavity by 37% in a mouse model of thioglycollate-induced peritonitis.
Intramuscular (i.m.) injection of RX-207 (1 mg/kg, 0.1 mL) inhibited carrageenan-induced paw edema in mice (32%).
RX-207 (30 uM) inhibited binding of the pro-inflammatory chemokine, MCP-3, to heparin, a highly sulfated form of the cell surface GAG, heparan sulfate.
RX-207 (30 μM) inhibited binding of the pro-inflammatory chemokine, IP-10, to the extracellular matrix GAG, chondroitin sulfate.
Physicochemical Properties
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M.Wt
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382.51
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Formula
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C22H30N4O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(C1=CC(N=C2N3CCCCC2)=C(C=C1)C3=O)NC4CCN(C(C)C)CC4
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References
1. Stefan Juhas, et al. Inflammation. 2018 Feb;41(1):307-314.
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