RX-5902 (Supinoxin, RX5902) is a small molecule inhibitor of phosphorylated-p68 RNA helicase (P-p68) and attenuates nuclear shuttling of β-catenin.
RX-5902 directly binds to Y593 phospho-p68 RNA helicase, exhibits strong growth inhibition in various human cancer cell lines with IC50 values ranging between 10 and 20 nM.
RX-5902 inhibited the β-catenin dependent ATPase activity of p68 RNA helicase, downregulates the expression of certain genes in β-catenin pathway, such as c-Myc, cyclin D1 and p-c-Jun.
RX-5902 inhibits β-catenin signaling and demonstrates anti-tumor activity in triple-negative breast cancer (TNBC) in vivo.
