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Chemical Structure : RXR agonist 33
Catalog No.: PC-21720Not For Human Use, Lab Use Only.
RXR agonist 33 is a highly potent, selective and partial RXR agonist with EC50 of 9/18/11 nM for RXRα/β/γ respectively.
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RXR agonist 33 is a highly potent, selective and partial RXR agonist with EC50 of 9/18/11 nM for RXRα/β/γ respectively.
RXR agonist 33 shows favorable selectivity profile with no off-target effect at 1 μM on nuclear receptors related to RXR.
RXR agonist 33 robustly activates human RXR homodimer response element DR1 with EC50 of 0.16 uM.
RXR agonist 33 induces the expression of the RXR homodimer-regulated glycerophosphodiester phosphodiesterase 1 (GDE1) in HT29 cells.
| M.Wt | 361.83 | |
| Formula | C18H20ClN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Max Lewandowski, et al. J Med Chem. 2024 Jan 18. doi: 10.1021/acs.jmedchem.3c02095.
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