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RXR agonist 33

Chemical Structure : RXR agonist 33

CAS No.:

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RXR agonist 33

Catalog No.: PC-21720Not For Human Use, Lab Use Only.

RXR agonist 33 is a highly potent, selective and partial RXR agonist with EC50 of 9/18/11 nM for RXRα/β/γ respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

RXR agonist 33 is a highly potent, selective and partial RXR agonist with EC50 of 9/18/11 nM for RXRα/β/γ respectively.
RXR agonist 33 shows favorable selectivity profile with no off-target effect at 1 μM on nuclear receptors related to RXR.
RXR agonist 33 robustly activates human RXR homodimer response element DR1 with EC50 of 0.16 uM.
RXR agonist 33 induces the expression of the RXR homodimer-regulated glycerophosphodiester phosphodiesterase 1 (GDE1) in HT29 cells.

Physicochemical Properties

M.Wt 361.83
Formula C18H20ClN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-((4-chloro-6-(4,4-dimethyl-3,4-dihydroquinolin-1(2H)-yl)pyrimidin-2-yl)oxy)propanoic acid

References

1. Max Lewandowski, et al. J Med Chem. 2024 Jan 18. doi: 10.1021/acs.jmedchem.3c02095.

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