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RapaLink-1

Chemical Structure : RapaLink-1

CAS No.: 1887095-82-0

RapaLink-1 (RapaLink 1, RapaLink1)

Catalog No.: PC-60418Not For Human Use, Lab Use Only.

RapaLink-1 is a third-generation mTOR inhibitor that overcomes resistance to existing first- and second-generation inhibitors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RapaLink-1 is a third-generation mTOR inhibitor that overcomes resistance to existing first- and second-generation inhibitors.
RapaLink-1 blocks mTOR signaling of the F2108L mTOR and M2327I mTOR drug resistant mutants.
RapaLink-1 is more potent mTOR inhibitor than rapamycin.

Physicochemical Properties

M.Wt 1784.165
Formula C91H138N12O24
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

40-O-(2-((1-(32-(4-amino-3-(2-aminobenzo[d]oxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-27-oxo-3,6,9,12,15,18,21,24-octaoxa-28-azadotriacontyl)-1H-1,2,3-triazol-4-yl)methoxy)ethyl)-rapamycin

References

1. Rodrik-Outmezguine VS, et al. Nature. 2016 Jun 9;534(7606):272-6.

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