Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-Rbin-1
Rbin-1

Chemical Structure : Rbin-1

CAS No.: 328023-11-6

Rbin-1 (Ribozinoindole-1)

Catalog No.: PC-42264Not For Human Use, Lab Use Only.

Rbin-1 (Ribozinoindole-1) is a potent, specific and reversible inhibitor of eukaryotic ribosome biogenesis that targets the AAA+ protein Midasin (IC40=1 uM).

Packing Price Stock Quantity
5 mg $78 In stock
10 mg $118 In stock
25 mg $218 In stock
50 mg $358 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Rbin-1 (Ribozinoindole-1) is a potent, specific and reversible inhibitor of eukaryotic ribosome biogenesis that targets the AAA+ protein Midasin (IC40=1 uM).
Rbin-1 inhibits the cell growth Wild-type fission yeast strains with GI50 of 136 nM, reduces the levels of Mdn1 in the Nsa1 particle.
Rbin-1 is a powerful probe for eukaryotic ribosome assembly.

Physicochemical Properties

M.Wt 256.3262
Formula C13H12N4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 31 mg/mL

Chemical Name/SMILES

5H-1,2,4-Triazino[5,6-b]indole, 3-[(2-methyl-2-propen-1-yl)thio]-

References

1. Kawashima SA, et al. Cell. 2016 Oct 6;167(2):512-524.e14.

2. Garbarino JE, et al. BMC Genomics. 2002;3:18.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: