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Reproxalap

Chemical Structure : Reproxalap

CAS No.: 916056-79-6

Reproxalap (ADX-102, ADX102)

Catalog No.: PC-72005Not For Human Use, Lab Use Only.

Reproxalap (ADX-102) is a novel inhibitor of reactive aldehyde species (RASP) for the treatment of ocular inflammation.

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Biological Activity

Reproxalap (ADX-102) is a novel inhibitor of reactive aldehyde species (RASP) for the treatment of ocular inflammation.
Reproxalap (ADX-102) protected octadecanal (C18:0-al) induced cytotoxicity and apoptosis in cellular model for SLS (Sjögren-Larsson syndrome), also inhibited etabolism of C18:0-al to fatty alcohol (octadecanol).
Reproxalap (ADX-102) is a novel small-molecule RASP inhibitor in development to treat NAU, allergic conjunctivitis, and dry eye disease.
Results from nonclinical studies indicate that reproxalap and related molecules have the potential to mitigate ocular inflammation related to NAU and other inflammatory eye conditions, such as postsurgical inflammation and diabetic retinopathy.

Physicochemical Properties

M.Wt 236.699
Formula C12H13ClN2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(3-Amino-6-chloroquinolin-2-yl)propan-2-ol

References

1. Mandell KJ, et al. J Ocul Pharmacol Ther. 2020 Dec;36(10):732-739.

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