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Retaspimycin hydrochloride

Chemical Structure : Retaspimycin hydrochloride

CAS No.: 857402-63-2

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Retaspimycin hydrochloride (IPI-504;IPI504;IPI 504)

Catalog No.: PC-42456Not For Human Use, Lab Use Only.

A water-soluble derivative of 17-AAG and HSP90 inhibitor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Retaspimycin hydrochloride (IPI-504) is a water-soluble derivative of 17-AAG and HSP90 inhibitor.
Retaspimycin hydrochloride (IPI-504) induces KIT degradation, tumor shrinkage, and cell proliferation arrest in xenograft models of gastrointestinal stromal tumors.

Physicochemical Properties

M.Wt 624.1652
Formula C31H46ClN3O8
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 56 mg/mL
Chemical Name/SMILES

Geldanamycin, 18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propen-1-ylamino)-, hydrochloride (1:1)

References

1. Floris G, et al. Mol Cancer Ther. 2011 Oct;10(10):1897-908.

2. Hanson BE, et al. Expert Opin Investig Drugs. 2009 Sep;18(9):1375-83.

3. Oh WK, et al. Urology. 2011 Sep;78(3):626-30.

4. Siegel D, et al. Leuk Lymphoma. 2011 Dec;52(12):2308-15.

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