Chemical Structure : Retinylamine
CAS No.:
43219-27-8
Retinylamine
(Ret-NH2)
Catalog No.: PC-28607Not For Human Use, Lab Use Only.
Retinylamine (Ret-NH2) is a potent inhibitor of the rod visual cycle, inhibits 11-cis-retinol production in isomerase assay with IC50 of 500 nM, potently and selectively inhibits the isomerization step of the retinoid cycle in vitro and in vivo.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Retinylamine (Ret-NH2) is a potent inhibitor of the rod visual cycle, inhibits 11-cis-retinol production in isomerase assay with IC50 of 500 nM, potently and selectively inhibits the isomerization step of the retinoid cycle in vitro and in vivo.
Retinylamine (Ret-NH2) binds a protein(s) in the RPE microsomes, but it does not bind RPE65, a protein implicated in the isomerization reaction.
Retinylamine (Ret-NH2) inhibits the regeneration of visual chromophore in rods and, in turn, severely attenuates rod responses, it has a much smaller effect on cone function in mice.
Retinylamine (Ret-NH2) inhibits regeneration of vision chromophore in vivo.
Physicochemical Properties
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M.Wt
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285.48
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Formula
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C20H31N
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-amine
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References
1. Wolber PK, et al. Proc Natl Acad Sci U S A. 1984 Apr;81(8):2303-7.
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