Rexipictor (VX-407) | Polycystin-1 corrector

Chemical Structure : Rexipictor

Rexipictor (VX-407, VX407)

Catalog No.: PC-27492Not For Human Use, Lab Use Only.

Rexipictor (VX-407) is a first-in-class small molecule Polycystin-1 (Polycystin 1, PC1, PKD1) corrector, corrects inappropriate PC1 folding to abate cystogenesis and eGFR decline, shows potential for treatment of autosomal dominant polycystic kidney disease (ADPKD).

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Biological Activity

Rexipictor (VX-407) is a first-in-class small molecule Polycystin-1 (Polycystin 1, PC1, PKD1) corrector, corrects inappropriate PC1 folding to abate cystogenesis and eGFR decline, shows potential for treatment of autosomal dominant polycystic kidney disease (ADPKD).

Physicochemical Properties

M.Wt	471.89
Formula	C23H20ClF2N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4H-Pyrazolo[4,3-c]pyridin-4-one, 5-[5-chloro-2-[[(1S)-1-cyclopropyl-2-hydroxyethyl]amino]-4-pyridinyl]-1-[(2,6-difluorophenyl)methyl]-1,5-dihydro-

References

1. Patent WO2025096453 A1 2025-05-08.

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Rexipictor (VX-407, VX407)

Biological Activity

Physicochemical Properties

References

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