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Rhoifolin

Chemical Structure : Rhoifolin

CAS No.: 17306-46-6

Rhoifolin

Catalog No.: PC-27550Not For Human Use, Lab Use Only.

Rhoifolin is a natural flavonoid with anti-inflammatory and antiparasitic potential, is a a direct potassium channel modulatory factor 1 (KCMF1) binder that stabilizes AMPKα and ameliorates MASLD, also inhibits the specific binding site of ALDH2-PKCδ, significantly increases chemosensitivity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Rhoifolin is a natural flavonoid with anti-inflammatory and antiparasitic potential, is a a direct potassium channel modulatory factor 1 (KCMF1) binder that stabilizes AMPKα and ameliorates MASLD, also inhibits the specific binding site of ALDH2-PKCδ, significantly increases chemosensitivity.
Rhoifolin selectively potentiates ILC3s effector function without affecting their proliferation, apoptosis, intestinal homing, developmental differentiation, or the distribution of CCR6+, NKp46+, and double-negative ILC3s subsets, directly targets NMNAT1.
Rhoifolin inhibits ferroptosis and alleviates pulmonary arterial hypertension via the TNF-alpha/TNF-R1/CASP8/CASP3 pathway.
Rhoifolin targets leukemia stem cells (LSCs) within the bone marrow microenvironment, work synergistically with conventional chemotherapy drugs, and exhibit no toxicity toward normal cells.

Physicochemical Properties

M.Wt 578.52
Formula C27H30O14
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

7-(((2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one

References

1. Kenzerki RE, et al. Sci Rep. 2026 Jun 6. doi: 10.1038/s41598-026-56709-w.

2. Yang H, et al. Adv Sci (Weinh). 2026 Aug 7:e76935.

3. Tang M, et al. Metabolism. 2026 Sep;182:156651.

4. Deng S, et al. Phytomedicine. 2026 Jun;155:158095.

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