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Chemical Structure : Rhonin
Catalog No.: PC-72867Not For Human Use, Lab Use Only.
Rhonin is the first small-molecule ligand of the RHO GDP-dissociation inhibitor 1 (RHOGDI1), binds to RHOGDI (Ki=2.2 uM), is an inhibitor of Hh-induced osteogenesis.
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Rhonin is a first small-molecule ligand of the RHO GDP-dissociation inhibitor 1 (RHOGDI1), binds to RHOGDI (Ki=2.2 uM), is an inhibitor of Hh-induced osteogenesis.
Rhonin interferes with its function by disrupting the interaction between RHOGDI and RHO GTPases.
Rhonin alters the subcellular localization of RHO GTPases.
Rhonin inhibited RHOGDI1-mediated extraction of RAC1 from liposomes, Rhonin increased the levels of GTP-bound RHO GTPases, did not alter the total levels of the three RHO GTPases
Rhonin an inhibitor of Hh-induced osteogenesis, but does not efficiently target canonical Hh signaling and SMO, directly targets RHOGDI, impairs RHOGDI function.
| M.Wt | 574.431 | |
| Formula | C29H24BrN3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mohammad Akbarzadeh, et al. Angew Chem Int Ed Engl. 2022 Feb 16;e202115193.
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