Risimtinib

Chemical Structure : Risimtinib

Catalog No.: PC-26354Not For Human Use, Lab Use Only.

Risimtinib (Compound 19a) is a highly potent FGFR inhibitor with IC50 of 2.1 nM against FGFR1, and 14.9 nM against the FGFR1-positive KG-1cancer cell.

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Biological Activity

Risimtinib (Compound 19a) is a highly potent FGFR inhibitor with IC50 of 2.1 nM against FGFR1, and 14.9 nM against the FGFR1-positive KG-1cancer cell.

Physicochemical Properties

M.Wt	509.61
Formula	C30H31N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Naphthalenecarboxamide, 6-[[2-[[4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzoyl]amino]-4-pyridinyl]oxy]-N-methyl-, rel-

References

1. Manman Wei, et al. Eur J Med Chem. 2018 Jun 25:154:9-28.

2. Patent WO2017140269 A1 2017-08-24.

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Risimtinib

Biological Activity

Physicochemical Properties

References

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