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Chemical Structure : Rivaroxaban
CAS No.: 366789-02-8
Catalog No.: PC-45897Not For Human Use, Lab Use Only.
Rivaroxaban (BAY 59-7939) is a highly potent and selective, direct FXa inhibitor with IC50 of 0.7 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $158 | In stock | |
| 200 mg | $248 | In stock | |
| 1 g | Get quote |
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Rivaroxaban (BAY 59-7939) is a highly potent and selective, direct FXa inhibitor with IC50 of 0.7 nM.
Rivaroxaban (BAY 59-7939) displays >10,000-fold greater selectivity than for other serine proteases, also inhibits prothrombinase activity (IC50=2.1 nM).
Rivaroxaban (BAY 59-7939) inhibits endogenous FXa more potently in human than rat plasma (IC50 21 nM vs 290 nM).
Rivaroxaban (BAY 59-7939) reduces venous thrombosis dose dependently (ED50=0.1 mg/kg i.v.) in a rat venous stasis model.
Rivaroxaban (BAY 59-7939) is orally active.
| M.Wt | 435.8813 | |
| Formula | C19H18ClN3O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Thiophenecarboxamide, 5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]- |
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1. Roehrig S, et al. J Med Chem. 2005 Sep 22;48(19):5900-8.
2. Perzborn E, et al. J Thromb Haemost. 2005 Mar;3(3):514-21.
3. Gerotziafas GT, et al. J Thromb Haemost. 2007 Apr;5(4):886-8.
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