Catalog No.: PC-36115Not For Human Use, Lab Use Only.
Ro 27-3225 (Ro27-3225, Ro 27-3225 trifluoroacetate salt) is a potent, selective melanocortin melanocortin receptor MC4R agonist with EC50 of 1 nM, >30-fold selectivity over MC3R.
Ro 27-3225 (Ro27-3225, Ro 27-3225 trifluoroacetate salt) is a potent, selective melanocortin melanocortin receptor MC4R agonist with EC50 of 1 nM, >30-fold selectivity over MC3R.
Ro 27-3225 shows some activity at the MC1 receptor (EC50=8 nM), reverses hemorrhagic shock, reduces multiple organ damage, and improves survival.
Physicochemical Properties
M.Wt
784.91 (free base)
Formula
C41H53F3N12O8
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Butir-His-D-Phe-Arg-Trp-Sar-NH2 trifluoracetate salt
References
1. Spaccapelo L, et al. Eur J Pharmacol. 2011 Nov 30;670(2-3):479-86.
2. Minutoli L, et al. Crit Care Med. 2011 May;39(5):1089-96.
3. Benoit SC, et al. J Neurosci. 2000 May 1;20(9):3442-8.
4. Agosti F, et al. Eur J Neurosci. 2014 Sep;40(5):2755-65.
