Ro 31-8220 mesylate | PKC inhibitor | Probechem Biochemicals

Chemical Structure : Ro 31-8220 mesylate

CAS No.: 138489-18-6

Ro 31-8220 mesylate (Bisindolylmaleimide IX mesylate)

Catalog No.: PC-23428Not For Human Use, Lab Use Only.

Ro 31-8220 mesylate (Bisindolylmaleimide IX) is a potent pan-PKC inhibitor with IC50 of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively.

Packing	Price	Stock
5 mg	$78	In stock
10 mg	$118	In stock
25 mg	$198	In stock
50 mg	$348	In stock
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Biological Activity

Ro 31-8220 mesylate (Bisindolylmaleimide IX) is a potent pan-PKC inhibitor with IC50 of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively.
Ro 31-8220 also inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7.
Ro 31-8220 has a 10-fold selectivity for PKC-alpha and a 4-fold selectivity for PKC-beta I over PKC-epsilon.
Ro 31-8220 inhibited the protein kinase C-mediated effect on inositol phosphate formation.

Physicochemical Properties

M.Wt	553.65
Formula	C26H27N5O5S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Carbamimidothioic acid, 3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester, methanesulfonate (1:1)

References

1. Wilkinson SE, et al. Biochem J. 1993 Sep 1;294 (Pt 2):335-7.

2. Davies SP, et al. Biochem J. 2000 Oct 1;351(Pt 1):95-105.

3. Dieter P, et al. Biochem Biophys Res Commun. 1991 Nov 27;181(1):396-401.

Ro 31-8220 mesylate (Bisindolylmaleimide IX mesylate)

Biological Activity

Physicochemical Properties

References

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