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Chemical Structure : Ro 31-8220 mesylate
CAS No.: 138489-18-6
Catalog No.: PC-23428Not For Human Use, Lab Use Only.
Ro 31-8220 mesylate (Bisindolylmaleimide IX) is a potent pan-PKC inhibitor with IC50 of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $348 | In stock | |
| 100 mg | Get quote |
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Ro 31-8220 mesylate (Bisindolylmaleimide IX) is a potent pan-PKC inhibitor with IC50 of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively.
Ro 31-8220 also inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7.
Ro 31-8220 has a 10-fold selectivity for PKC-alpha and a 4-fold selectivity for PKC-beta I over PKC-epsilon.
Ro 31-8220 inhibited the protein kinase C-mediated effect on inositol phosphate formation.
| M.Wt | 553.65 | |
| Formula | C26H27N5O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Carbamimidothioic acid, 3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester, methanesulfonate (1:1) |
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1. Wilkinson SE, et al. Biochem J. 1993 Sep 1;294 (Pt 2):335-7.
2. Davies SP, et al. Biochem J. 2000 Oct 1;351(Pt 1):95-105.
3. Dieter P, et al. Biochem Biophys Res Commun. 1991 Nov 27;181(1):396-401.
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