Ro 48-8071 is a potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM.
Ro 48-8071 is 6 times less potent against hamster and Gottingen minipig liver OSC, and 10-times more potent against squirrel monkey liver OSC.
Ro 48-8071 blocks human liver OSC and cholesterol synthesis in HepG2 cells in the nanomolar range.
Ro 48-8071 triggers the production of monooxidosqualene, dioxidosqualene, and epoxycholesterol.
