Ro 48-8071 fumarate |CAS:189197-69-1 Probechem Biochemicals

Chemical Structure : Ro 48-8071 fumarate

CAS No.: 189197-69-1

Ro 48-8071 fumarate (Ro-488071 fumarate)

Catalog No.: PC-45493Not For Human Use, Lab Use Only.

Ro 48-8071 fumarate is a potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM.

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25 mg	$128	In stock
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Biological Activity

Ro 48-8071 fumarate is a potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM.
Ro 48-8071 fumarate is 6 times less potent against hamster and Gottingen minipig liver OSC, and 10-times more potent against squirrel monkey liver OSC.
Ro 48-8071 fumarate blocks human liver OSC and cholesterol synthesis in HepG2 cells in the nanomolar range.
Ro 48-8071 fumarate triggers the production of monooxidosqualene, dioxidosqualene, and epoxycholesterol.

Physicochemical Properties

M.Wt	564.4406
Formula	C27H31BrFNO6
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 55 mg/mL
Chemical Name/SMILES	Methanone, (4-bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]-, (2E)-2-butenedioate (1:1)

References

1. Morand OH, et al. J Lipid Res. 1997 Feb;38(2):373-90.

2. Peffley DM, et al. Biochem Pharmacol. 1998 Aug 15;56(4):439-49.

3. Liang Y, et al. Onco Targets Ther. 2016 May 30;9:3223-32.

Ro 48-8071 fumarate (Ro-488071 fumarate)

Biological Activity

Physicochemical Properties

References

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