You are here:Home-Chemical Inhibitors & Agonists-Nuclear Receptor/Transcription Factor-RUNX1-CBFβ-Ro5-3335
Ro5-3335

Chemical Structure : Ro5-3335

CAS No.: 30195-30-3

Ro5-3335 (NSC 66020;Ro 5-3335;Ro 53335)

Catalog No.: PC-70219Not For Human Use, Lab Use Only.

Ro5-3335 is a small molecule RUNX1-CBFβ interaction inhibitor that represses RUNX1/CBFB-dependent transactivation

Packing Price Stock Quantity
10 mg $198 In stock
25 mg $298 In stock
50 mg $458 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ro5-3335 is a small molecule RUNX1-CBFβ interaction inhibitor that represses RUNX1/CBFB-dependent transactivation.
Ro5-3335 repressed runx1-dependent hematopoiesis in zebrafish embryos.
Ro5-3335 preferentially killed human CBF leukemia cell lines, rescued preleukemic phenotype in a RUNX1-ETO transgenic zebrafish, and reduced leukemia burden in a mouse CBFB-MYH11 leukemia model.
Ro5-3335 enhance the activation of latent HIV-1 in both cell lines and PBMCs from patients when synergizes with the histone deacetylase (HDAC) inhibitor SAHA.

Physicochemical Properties

M.Wt 259.63
Formula C13H10ClN3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one

References

1. Cunningham L, et al. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14592-7.

2. Bresciani E, et al. Blood. 2014 Jul 3;124(1):70-8.

3. Logan TT, et al. Stem Cell Res. 2015 Nov;15(3):554-64.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: