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Chemical Structure : Ro 90-7501
Catalog No.: PC-73339Not For Human Use, Lab Use Only.
Ro 90-7501 is a prototypic inhibitor for Abeta42 (Aβ42) fibril formation, reduces Aβ42-induced cytotoxicity (EC50=2 uM), also enhances TLR3 and RLR agonist induced antiviral response.
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Ro 90-7501 is a prototypic inhibitor for Abeta42 (Aβ42) fibril formation, reduces Aβ42-induced cytotoxicity (EC50=2 uM), also enhances TLR3 and RLR agonist induced antiviral response.
Ro 90-7501 also inhibits protein phosphatase 5 (PP5) through a TPR-dependent mechanism.
Ro 90-7501 also showed significant radiosensitizing effects in clonogenic survival and tumor growth delay assays suppressed the phosphorylation of ATM and its downstream proteins, such as H2AX, Chk1, and Chk2, after irradiation.
| M.Wt | 340.390 | |
| Formula | C20H16N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bohrmann B, et al. J Struct Biol. 2000 Jun;130(2-3):232-46.
2. Guo F, et al. PLoS One. 2012;7(10):e42583.
3. Hong TJ, et al. Biochem Biophys Res Commun. 2017 Jan 8;482(2):215-220.
4. Tamari K, et al. Anticancer Res. 2019 Sep;39(9):4805-4810.
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