Catalog No.: PC-62182Not For Human Use, Lab Use Only.
Robotnikinin is a small molecule that binds the extracellular Sonic Hedgehog (Shh) protein (Kd=3.1 uM) and blocks Shh-signaling in cell lines, human primary keratinocytes and synthetic model of human skin.
Robotnikinin is a small molecule that binds the extracellular Sonic Hedgehog (Shh) protein (Kd=3.1 uM) and blocks Shh-signaling in cell lines, human primary keratinocytes and synthetic model of human skin.
Robotnikinin displays significant repression of Shh-induced Gli1/Gli2.
Robotnikinin interferes with the ability of the ShhN protein complex to relay its signal efficiently to Ptc1.
