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Chemical Structure : Ronacaleret hydrochloride
CAS No.: 702686-96-2
Catalog No.: PC-61506Not For Human Use, Lab Use Only.
Ronacaleret (SB751689) hydrochloride is a potent calcium sensing receptor (CaSR) negative allosteric modulator with IC50 of 146 nM for hCaSR.
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|---|---|---|---|
| 5 mg | $488 | In stock | |
| 10 mg | $788 | In stock | |
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| 100 mg | Get quote |
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Ronacaleret (SB751689) hydrochloride is a potent calcium sensing receptor (CaSR) negative allosteric modulator with IC50 of 146 nM for hCaSR.
Ronacaleret stimulates parathyroid hormone (PTH) release and increases bone formation markers.
Ronacaleret act as an effective oral anabolic agent to enhance fracture healing.
| M.Wt | 483.98 | |
| Formula | C25H32ClF2NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-[3-[(2R)-3-[[1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]-4,5-difluorophenyl]propanoic acid hydrochloride |
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1. Balan G, et al. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3328-32.
2. Fitzpatrick LA, et al. J Clin Endocrinol Metab. 2011 Aug;96(8):2441-9.
3. Fitzpatrick LA, et al. Bone. 2011 Oct;49(4):845-52.
4. Caltabiano S, et al. Bone. 2013 Sep;56(1):154-62.
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