Chemical Structure : Ropsacitinib
CAS No.:
2127109-84-4
Ropsacitinib
(PF-06826647)
Catalog No. : PC-72613Not For Human Use, Lab Use Only.
Ropsacitinib (PF-06826647) is a potent, selective TYK2 inhibitor with IC50 of 15 nM, inhibits JAK1/2/3 with IC50 of 383/74/>10,000 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-7261301
Biological Activity
Ropsacitinib (PF-06826647) is a potent, selective TYK2 inhibitor with IC50 of 15 nM, inhibits JAK1/2/3 with IC50 of 383/74/>10,000 nM.
Physicochemical Properties
M.Wt
383.419
Formula
C20H17N9
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO (3.8 mg/mL)
Chemical Name/SMILES
(1r,3r)-3-(cyanomethyl)-3-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutane-1-carbonitrile
References
1. Gerstenberger BS, et al. J Med Chem.
2. Singh RSP, et al. Clin Transl Sci.
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