Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Rosiglitazone
CAS No.: 122320-73-4
Catalog No.: PC-45209Not For Human Use, Lab Use Only.
Rosiglitazone (BRL49653) is a potent and selective PPARγ agonist that binds to the PPARγ ligand-binding domain with a Kd of 40 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg (Free Sample) | $28 | In stock | |
| 50 mg | $88 | In stock | |
| 100 mg | $128 | In stock | |
| 250 mg | $188 | In stock | |
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Rosiglitazone (BRL49653) is a potent and selective PPARγ agonist that binds to the PPARγ ligand-binding domain with a Kd of 40 nM.
Rosiglitazone (BRL49653) is an antidiabetic agent that has been used as an oral hypoglycemic agent in the treatment of Type II diabetes.
Rosiglitazone (BRL49653) also inhibits TRP channels TRPM2 and TRPM3 with IC50 of 22.5 uM and 5-10 uM, respectively.
Rosiglitazone (BRL49653) also increases klotho and decreases Wnt5A in tumor cells.
| M.Wt | 357.4268 | |
| Formula | C18H19N3O3S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: ≥ 180 mg/mL |
|
| Chemical Name/SMILES |
2,4-Thiazolidinedione, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]- |
|
1. Lehmann JM, et al. J Biol Chem. 1995 Jun 2;270(22):12953-6.
2. Majeed Y, et al. Mol Pharmacol. 2011 Jun;79(6):1023-30.
3. Behera R, et al. Clin Cancer Res. 2017 Jun 15;23(12):3181-3190.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
