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Chemical Structure : Rotigotine
CAS No.: 99755-59-6
Catalog No.: PC-45959Not For Human Use, Lab Use Only.
A non-selective agonist of the dopamine D3 receptor (Ki=0.71 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $224 | In stock | |
| 100 mg | $320 | In stock |
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A non-selective agonist of the dopamine D3 receptor (Ki=0.71 nM); has 10-fold selectivity for the D3 receptor over the D2, D4, and D5 receptors and 100-fold selectivity for the D3 receptor over the D1 receptor; behaves as a full agonist of D1, D2, and D3 with similar potencies (EC50) in functional assay; also demonstrates significant affinity at α-adrenergic (α2B, Ki=27 nM) and serotonin receptors (5-HT1A Ki=30 nM); significantly attenuates MPTP-induced acute cell degeneration in mouse model.
Parkinson's Disease
Approved
| M.Wt | 315.4729 | |
| Formula | C19H25NOS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-, (6S)- |
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1. Wood M, et al. Br J Pharmacol. 2015 Feb;172(4):1124-35.
2. Scheller D, et al. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):73-86.
3. Scheller D, et al. Neurosci Lett. 2008 Feb 13;432(1):30-4.
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