Ru360 | MCU inhibitor | Probechem Biochemicals

Chemical Structure : Ru360

Ru360 (Ru-360, Ru 360)

Catalog No.: PC-60650Not For Human Use, Lab Use Only.

Ru360 is a cell-permeable mitochondrial calcium uptake (MCU) inhibitor that binds to mitochondria with high affinity (Kd=340 pM) and blocks Ca2+ uptake into mitochondria in vitro with IC50 of 184 pM.

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Biological Activity

Ru360 is a cell-permeable mitochondrial calcium uptake (MCU) inhibitor that binds to mitochondria with high affinity (Kd=340 pM) and blocks Ca2+ uptake into mitochondria in vitro with IC50 of 184 pM.
Ru360 inhibits the flow of calcium into mitochondria and prevents the opening of the mitochondrial permeability transition pore,.
Ru360 improves cardiac post-ischaemic functional recovery in rats in vivo.

Physicochemical Properties

M.Wt	550.78
Formula	C2H26N8O5Ru2•3Cl
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

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Ru360 (Ru-360, Ru 360)

Biological Activity

Physicochemical Properties

References

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