Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Ruboxistaurin
CAS No.: 169939-94-0
Catalog No.: PC-23429Not For Human Use, Lab Use Only.
Ruboxistaurin (LY333531) is a potent, selective, ATP-competitive, orally available PKC beta (PKCβ) inhibitor with IC50 of 4.7 and 5.9 nM for PKCβ I and PKCβ II, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | $598 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Ruboxistaurin (LY333531) is a potent, selective, ATP-competitive, orally available PKC beta (PKCβ) inhibitor with IC50 of 4.7 and 5.9 nM for PKCβ I and PKCβ II, respectively.
Ruboxistaurin hydrochloride (LY333531) displays >60-fold selectivity over PKCα, and other ATP dependent kinases (PKA, Calcium calmodulin, Caesin kinase and Src).
Ruboxistaurin hydrochloride (LY333531) ameliorates the glomerular filtration rate, albumin excretion rate, and retinal circulation in diabetic rats.
| M.Wt | 468.56 | |
| Formula | C28H28N4O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(7S)-7-((Dimethylamino)methyl)-22,25-dihydro-11H,21H,31H-6-oxa-1,3(3,1)-diindola-2(3,4)-pyrrolacyclononaphane-22,25-dione |
|
1. Jirousek MR, et al. J Med Chem. 1996 Jul 5;39(14):2664-71.
2. Ishii H, et al. Science. 1996 May 3;272(5262):728-31.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
